Sure,
Code:
PdfDocument document = new PdfDocument();
PdfPage page = document.AddPage();
XGraphics gfx = XGraphics.FromPdfPage(page);
XPdfFontOptions options = new XPdfFontOptions(PdfFontEncoding.Unicode, PdfFontEmbedding.Always);
//other things going on here ... drawing on the gfx
PdfSharp.Drawing.XRect rectt = gfx.Transformer.WorldToDefaultPage(new PdfSharp.Drawing.XRect(Convert.ToInt32(item.Attributes["X1"].Value),
height Convert.ToInt32(item.Attributes["Y1"].Value),
Convert.ToInt32(item.Attributes["X2"].Value),
height Convert.ToInt32(item.Attributes["Y2"].Value)));
PdfSharp.Pdf.PdfRectangle rc = new PdfSharp.Pdf.PdfRectangle(rectt);
page.AddWebLink(rc, "http://www.google.com");
PdfSecuritySettings securitySettings = document.SecuritySettings;
securitySettings.PermitAccessibilityExtractContent = PermitExtractContent;
securitySettings.PermitAnnotations = false;
securitySettings.PermitAssembleDocument = false;
securitySettings.PermitExtractContent = PermitExtractContent;
securitySettings.PermitFormsFill = true;
securitySettings.PermitFullQualityPrint = PermitPrint;
securitySettings.PermitModifyDocument = false;
securitySettings.PermitPrint = PermitPrint;